DETECTION OF SERUM HOMOCYSTEINE LEVEL AND IT'S CORRELATION WITH MEAN ARTERIAL PRESSURE IN PRE ECLAMPSIA AND ECLAMPSIA

Abstract

Objective :Plasma Homocysteine level and  its correlation with Mean Arterial Pressure in Pre eclampsia and eclampsia.

Method : The  present study was conducted in 150 antenatal women with normotensive and hypertensive pregnancy attending out patient , in Swaroop Rani Nehru Hospital and Kamla Nehru Memorial Hospital, Department of Obstetrics and Gynaecology, Prayagraj over a period of 12 month from August 2018 to July 2019. 25(31.25%) cases had MAP in range of  100-120, 55(68.75%) cases had >120, in study group. Mean value in study group 123.54±9.09 compared to mean value in control group was 97.60±7.67 .p<0.001which is highly significant. Positive correlation was present between serum homocysteine and MEAN ARTERIAL PRESSURE ( r=0.45) 

Result: Women with raised blood pressure are at risk of developing Pre eclampsia and Eclampsia , and  it serves as a predictive marker of pre eclampsia. Serum homocysteine was significantly increased in Eclampsia, severe Pre eclampsia and mild Pre eclampsia in comparison to control group.

Conclusion: High levels of homocysteine may be considered a precocious marker of vascular damage and may denote a higher risk of preeclampsia and elevated level of serum homocysteine may be associated with severity of pre-eclampsia.