Pali Rastogi, Arpita Thakur, Ram ghulam Razdan


Objective of the study

The objective of the study was to assess and compare serum calcium and magnesium level in Depression patients and healthy controls and to find out correlation of serum Mg++ and Ca++ levels with Depression. Depression is reported to be the most common mood disorder which can be manifest as a single episode or as recurrent episodes. Globally, the proportion of the population affected with depression is estimated to be 4.4%. In one of the reports of the World Health Organization, depression and heart disease will be the most common diseases on Earth by 2020. Methodology: The study is based on a sample of 200 subjects – 100 healthy normal individuals and 100 patients, from Department of Psychiatry, Mahatma Gandhi Memorial Medical College and M. Y. Hospital, Indore, who were diagnosed as having Depression as per the ICD-10 criteria. Estimation of the parameters of the study was done by using spectrophotometer (Spectra scan UV 2600). The result values of both the groups were compared by using SPSS 23 for windows were used for data analysis. Results: Analysis of data reveals the mean value of serum magnesium among subjects of the case group was lowered then compared to the subjects of the control group. The differences in mean values were found to be statistically significant. While in case of serum calcium, Case group has shown less serum calcium levels than control group, but it was not statistically significant. Conclusion: The present study shows that alterations in the concentrations of magnesium and calcium may play a role in depressive illnesses and thus, may have a possible role in causing various mood disorders like MDD.


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