THE DIFFERENCE OF INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR EXPRESSION IN BREAST CANCER PATIENTS WHO ARE SUFFERING AND NOT DIABETES MELLITUS TYPE 2 IN ADAM MALIK HOSPITAL

Rafki Hidayat, Kamal Basri Siregar, Kamal Basri Siregar, Dr. Suyatno, Dr. Suyatno

Abstract


Background: Breast cancer is a global problem and a prominent international health issue, including the most common
malignancies in women in developed countries. Like breast cancer, diabetes mellitus (DM) is still a global problem,
especially in developed countries. This study would like to see the difference of insulin-like growth factor 1 receptor
expression in diabetic breast cancer patients and non-diabetic breast cancer patients.
Methods: The design of this study is case-control, with the patients included in this study are the breast cancer patients
with or without a history of type 2 DM who already had an examination of insulin growth factor (IGF) histopathology. The
statistical analysis was done with chi-square analysis to determine the relationship between the overexpression of the
IGF1 receptor (IGF1R) and the history of type 2 diabetes mellitus (DM).
Result: There was a statistically significant difference between the overexpression of the IGF1R incident and a history of
type 2 DM in a patient with breast cancer (p = 0.001, OR: 4.9; 95% CI 1.898 – 12.697). Further analysis of the sample
characteristics also showed a significant difference between the overexpression of IGF1R incident and the incident of
distant metastasis (p = 0.049).
Conclusion: In this study, it was found that there was a significant difference in the expression of IGF1R in breast cancer
patients suffering from and not type 2 diabetes mellitus; and could be a predictor of breast cancer, especially in patients
with diabetes mellitus.


Keywords


Breast Cancer, Type 2 Diabetes Mellitus, Insulin Growth Factor 1 Receptor

Full Text:

PDF

Refbacks

  • There are currently no refbacks.