THE CORRELATION BETWEEN SERUM THYROID HORMONE LEVELS AND FIRST EPISODE OF MAJOR DEPRESSIVE DISORDER

Pal V. S, Chauhan Beema, Rastogi Pali, Razdan R

Abstract


Background: Hypothalamus-pituitary-thyroid (HPT) axis dysfunction has been connected with pathophysiology of
depression. The object of this study was to determine serum level of free 3,5,3'-triiodothyronine (T3), free thyroxine (T4)
and thyroid-stimulating-hormone (TSH) in drug naive patients with unipolar depression and healthy controls.
Methodology: The study included 100 medication-free patients with unipolar depression and 100 healthy controls.
Results: A higher FT4, lower FT3 and lower TSH mean values which were statistically significant as compared to healthy
controls however the means were still in the euthyroid range.
Conclusion: The results showing altered levels of thyroid hormones in depression advisable that further research on
thyroid hormone activity can contribute to the greater understanding of the biological basis of depression.


Keywords


first episode depression, free T3, Free T4, thyroid stimulating hormone(TSH)

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