STUDY THE EFFECT OF TRANEXAMIC ACID IN REDUCING POSTOPERATIVE BLOOD LOSS IN CEMENTLESS TOTAL HIP ARTHROPLASTY

Dr Sunil Kumar Rawat, Dr Sanjeev Kansotiya, Dr Ashok Kumar Kuldeep

Abstract


Several techniques are available to minimize the likelihood of allogenic blood transfusion following the hip arthroplasty including intra-operative red cell salvage local anaesthesia, controlled hypotension and use of antifibrinolytics like tranexamic acid .  The double blinded, placebo control hospital based interventional study was conducted on 60 patients by dividing them randomly in control and study group(TA), 30 patients in each group to study the effects of 1000 mg single dose of intravenous tranexamic acid in reducing postoperative blood loss in cementless total hip arthroplasty using American Society of Anaesthesiologists (ASA) grading system. We included in our study all patients less than 60 year of age except 2 patients. 30 patients were less than 40 year and 30 patients were greater than 40 years. The difference between the control group and the tranexamic acid group was significant (P value <.001) in all time intervals. In this study no significant difference was found in postoperative blood loss in age group <40 year and age group >40 years (P value >.05) in TA group.


Keywords


Blood loss, cementless total hip replacement, postoperative, tranexamic acid.

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