A STUDY OF ASSOCIATION BETWEEN SERUM URIC ACID LEVELS WITH VARIOUS COMPONENTS OF METABOLIC SYNDROME

Dr. Rajeev Bhardwaj, Dr. Rajesh Jain

Abstract


Background : The metabolic syndrome is a widely prevalent and multi-factorial disorder that presents in a distinct, heterogeneous phenotype. The clinical relevance of the metabolic syndrome is related to its role in the development of cardiovascular disease. The major features of the Metabolic Syndrome include central obesity, Hyper-triglyceridemia, low high-density lipoprotein (HDL) cholesterol, Hyperglycemia and Hypertension. Mean serum uric acid levels vary with variable components of metabolic syndrome. There is a direct linear relationship between serum uric acid level and number of metabolic syndrome patients. Increased levels of serum uric acid should be considered as an important marker in patients with metabolic syndrome and Hyperuricemia is an associated abnormality that should be considered in those with metabolic syndrome. Aim & Objective : To evaluate the association between serum uric acid and metabolic syndrome and correlation of uric acid levels with various components of metabolic syndrome. Material and Method: This study was conducted among 100 patients with metabolic syndrome (cases) admitted in JLN hospital Ajmer and 100 subjects (age and sex matched controls) who do not have any component of metabolic syndrome. The subjects for the study were selected from the patients attending medical outdoor and admitted in various medical wards and MICU from Jan 2018 to Oct 2019. Total of 100 subjects of old and newly diagnosed metabolic syndrome on the basis of NCEP ATP III CRITERIA and Both sex (male and female) greater than 18 years of age who have given consent to participate in the study were included and Patients with severe liver dysfunction, renal failure, known malignant disease, chronic inflammatory disease such as rheumatoid arthritis, gout, tuberculosis and sarcoidosis, history of acute myocardial infarction and history of CVA were excluded. Result: It is seen when mean serum uric acid of triglycerides, HDL, Fasting plasma glucose, Blood Pressure and WC was compared to mean of uric acid of controls, results was significant. Conclusion: Hyperuricemia should be considered as a component of metabolic syndrome and risk factor for cardiovascular diseases.


Keywords


Metabolic Syndrome, Hyperuricemia, Hyperlipidemia, Hyperglycemia.

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