AMELIORATIVE EFFECT OF ZINGERONE AGAINST LEAD INDUCED SPLEEN TOXICITY OF SWISS ALBINO MICE (MUS MUSCULUS)

Papiya Datta, Dr. Soumosish Paul, Dr. Koustav Dutta Chowdhury, Gobinda Chandra Sadhukhan, Dr. Soumendranath Chatterjee

Abstract


Lead is a toxic heavy metal found in earth crust. Poisoning of lead is a serious global problem for a long time. The experiment was conducted to
explain the preventive effect of Zingerone against lead poisoning. Toxicity of lead was assessed by applying lead acetate to healthy Swiss albino
mice (Mus musculus) for 12 weeks continuously followed by administration of Zingerone along with lead by oral gavage at selected doses for 4
weeks. Morphological, biochemical and histological parameters were done to show the ill effects of lead on spleen in dose dependent manner.
Application of Zingerone at a specific dose resulted in a significant reduction of the above parameters. Thus this herbal drug offers a significant
ameliorating effect against lead toxicity.


Keywords


Lead, Zingerone, Toxicity-amelioration, Swiss albino mice.

Full Text:

PDF

Refbacks

  • There are currently no refbacks.