INFLAMMATORY BIOMARKERS IN MIGRAINE- A PROSPECTIVE OBSERVATIONAL STUDY

Rahul Mahajan, Kuljeet Singh Anand, Rakesh Kumar Mahajan, Abhishek Juneja

Abstract


BACKGROUND-Neurogenic inflammation during migraine attacks may lead to raised serum inflammatory markers like hsCRP and
procalcitonin.
OBJECTIVES- To determine the serum levels of hsCRP and procalcitonin in patients of migraine during attack and in between attacks as
compared to healthy controls.
METHODS-This study was conducted on 50 consecutive patients of migraine fulfilling inclusion criteria and same number of healthy controls.
The patients of migraine were diagnosed on the basis of International Classification of Headache Disorders 3rd Edition.
RESULTS- Mean serum hsCRP was significantly higher in migraine cases than in healthy controls, which was further raised during acute
attack.Serum procalcitonin during acute attack of migraine was higher in significant proportion of cases when compared to interictal phase
(p=0.025).
CONCLUSION-Migraine is a proinflammatory state which may have its implication in increased risk of stroke in migraine patients as reported by
some past studies and these biomarkers may help in identifying patients at risk.


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