CLINICAL EFFECTS OF LEVAMISOLE AND ANTIOXIDANTS AND THEIR EFFECTS ON SERUM IMMUNOGLOBULINS IGG, IGA AND IGM: A COMPARATIVE CLINICAL STUDY IN MANAGEMENT OF OSMF.

Dr Akshay Sharma, Dr Sonam Tyagi, Dr Saddam

Abstract


BACKGROUND AND OBJECTIVES: Oral submucous fibrosis (OSMF) is considered as an oral precancerous condition that shows
characteristic inflammation and progressive fibrosis of the submucosal tissues that leads to marked rigidity as well astrismus. OSMF till date
remains a dilemma to the oral pathologists due to its ambiguous pathogenesis and overlapping classification systems.OSMF is linked with
alterations in serum immunoglobulins levels.
AIM: This study was conducted to evaluate the clinical effects of levamisole and antioxidants and their effects on serum immunoglobulins IgG,
IgA and IgM levels.
MATERIALS AND METHODS: 45 study participants were enrolled for the study. Subjects were assigned randomly into 3 sub-groups. There
were 15 patients per group; group I comprised of patients who received levamisole, 50 mg thrice daily for three alternate weeks, group II comprised
of patients who received 2 capsules of antoxid daily for six weeks, group III comprised of patients who received levamisole and antioxidant both.
RESULTS:Paired't' test and unpaired't' test were used to assess the study results. The results were clearly indicative of the advantage oftaking
levamisole, antoxid and the combination of levamisole and antoxid in improving mouth opening and reducing burning sensation of mouth
significantly. Significant decrease in serum IgG, IgA and IgM was observed in group I and combination group III whereas in the group II significant
reduction was only seen in serum IgA and IgM levels.
CONCLUSION: Levamisole alone has a higher advantage in clinical management of OSMF when compared to that of antioxidant therapy alone
or in combination. Antioxidants proved to have no added benefit in aiding to the reduction in burning sensation or in opening of restricted oral
cavity.


Keywords


Oral Submucous Fibrosis,immunoglobulins, Levamisole, Antoxid

Full Text:

PDF

Refbacks

  • There are currently no refbacks.