A STUDY ON EFFECTIVENESS OF PRE OPERATIVE V/S POST OPERATIVE MISOPROSTOL ADMINISTRATION IN CEASEREAN SECTION.

Abstract

Purpose: To compare the effectiveness of the rec+tally administered misoprostol pre-operative versus post-operative in minimizing intraoperative
blood loss and prevention of postpartum hemorrhage in cesarean delivery.
Material and Methods: This study included 180 pregnant women at term (37 - 40 weeks) undergoing Caesarean delivery under regional
anesthesia. Group I (n = 84) received 400μg rectal misoprostol preoperatively, and Group II (n = 82) received 400μg rectal misoprostol
postoperatively. Hematocrit level was measured and recorded at admission as a preoperative routine investigation and repeated 24 hours following
cesarean delivery . The patients were evaluated in terms of operative time,operative blood loss and any side effects of administered drugs.
Results: The demographic characteristics of participants as age ,parity and gestational age were comparable between the two groups. As regard the
estimated blood loss (M ± SD) during cesarean section in group I (preoperative misoprostol) was 372.33 ± 25.997 ml, in group II (postoperative
misoprostol) was 722 ± 34.089 ml (p = 0.001). Hematocrit value after cesarean section was significantly lower in group II than in group I (P = <
0.001). The 2 groups were not different in terms of side-effects except for abdominal pain (P value0.02).
Conclusion: Administration of rectal misoprostol prior cases are an appears to be safe, more effective than post operative administration for
decreasing the amount of blood loss during cesarean section.