SERUM MALONDIALDEHYDE (MDA) LEVELS AND LIPID PROFILE PATTERN IN THE PATIENTS WITH ACUTE MYOCARDIAL INFARCTION (AMI)

Nandu Baby P, Dr V. Ramesh Ph.D

Abstract


Acute Myocardial Infarction (AMI) is one of the critical emergencies of cardiovascular events leading to increased mortality rate and sudden deaths. Multiple arrays of biomarkers are required for its diagnosis and prognosis. To investigate serum Malondialdehyde (MDA) levels as an indicative of oxidative stress and comparison of lipid profile pattern in AMI patients. This is a prospective case- control study carried out in a tertiary care hospital between July and December 2017. The study recruited 100 consecutive AMI patients from the department of cardiology and 100 control subjects were recruited without  the history of MI. Fasting (12 hours) blood samples was collected from all the subjects from ante-cubital vein and aliquated in to vials. MDA was measured using thio-barbituric acid method. Total cholesterol (TC) was estimated by Triender CHOD/PODend point method, triglycerides (TG) by GPO/POD enzymatic colorimetric method. High density lipoprotein (HDL) cholesterol was estimated using PEG-CHO-POD end point method. Low density lipoprotein (LDL) cholesterol was assessed by using the Friedewald formula. We observed notably higher levels of MDA in AMI patients (607±76nmol/dl) than in control subjects (230 ± 26nmol/dl) (p< 0.05). The lipid profile including serum triglycerides(TG), total cholesterol(TC), low-density lipoproteins (LDL), very-low density lipoproteins(VLDL) cholesterols were also significantly higher compared to controls (p<0.001). The High-density lipoproteins (HDL) levels are significantly lower in MI patients than in controls.  Oxidative stress contributes in the pathogenesis of AMI. Therefore, oxidative stress biomarkers like malondialdehyde can be of good predictors for risk of AMI.


Keywords


Malondialdehyde, Oxidative stress, Acute myocardial infarction, Lipid profile.

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