EXTENDED SPECTRUM B- LACTAMASES ( ESBL ) PRODUCER E.COLI IN CAUTI IN ICU PATIENTS IN NORTH BIHAR.

Dr. Amit Prakash, Dr. Ranjeet Kumar

Abstract


Extended-spectrum β-lactamases (ESBL) producing micro-organism  increases infection in catheter associated (CAUTI) urinanary tract infection  and  led to limitations of treatment options. The aim of our  study is to know the prevalence of ESBL producing E. coli spp. at a tertiary hospital in north bihar.

Methods: A total of 250 mid-stream urine (MSU) samples were collected during the study period from October 2017 to September 2019. Identification of the isolates was done by Gram's staining followed by biochemical tests. ESBL screening among E. coli spp. isolates were  done by phenotypic disc diffusion test method  (combined disc method) using ceftazidime (30µg) and ceftazidime plus clavulanic acid (30/10µg).

Results: A total of 150 samples showed significant bacteriuria with 30 (20 %) E. coli. By combined disk test, 20 (66.6%) E. coli  spp. were found ESBL producers.

Conclusion:  Prevalence of ESBL producing E. coli spp. is high among catheter associated urinary tract infection.  Prompt  effective diagonosis and  management of  MDR strains is necessary in clinical setting to decrease morbidity among admitted patients .


Keywords


intensive care units (ICU), EXTENDED SPECTRUM B- LACTAMASES ( ESBL), mid-stream urine (MSU)

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