A RANDOMISED CONTROL STUDY OF DEXMEDETOMIDINE VERSUS FENTANYL AS AN ANAESTHETIC ADJUVANT TO GENERAL ANAESTHESIA IN LAPAROSCOPIC SURGERIES

L S Mishra, Vaibhav Singh, Birendra Kumar Raw, Sandeep Kumar

Abstract


Aim: To compare the effect of Dexmedetomidine and Fentanyl in relation to blunting of sympathetic response to intubation and induction while secondary variables are to study their effect on perioperative hemodynamic changes, operative conditions, recovery profile and side effects.

Methods: This study was conducted on 100 patients, divided into two groups (Group D and Group F) {50 Patients in each group} of either sex between 18 to 60 years of age, belonging to ASA physical status I – II, undergoing elective laparoscopic surgeries. Patients were randomised by using sealed envelope method. Group D : Patients received 1 µg/kg of Dexmedetomidine intravenous infusion as loading dose over 10 min before induction and 0.04-0.05 µg/kg/min of Dexmedetomidine as maintenance during surgery. Group F : Patients received 2 µg/kg of Fentanyl before induction and maintained with 0.02-0.03 µg/kg/min of Fentanyl intravenous infusion during surgery. In operating room parameters like Heart Rate (HR), Systolic Blood Pressure (SBP), Mean Arterial Pressure (MAP), SpO2 , EtCO2 were recorded before and 10 minutes after infusion of drug i.e., dexmedetomidine or fentanyl. The said parameters were recorded at different time interval.

Results: Dexmedetomidine significantly attenuates stress response at intubation with lesser increase in HR (4.2% Vs 27%) and MAP (4.2% Vs 17.4%) as compared to fentanyl (p<0.05). Throughout intraoperative period of pneumoperitoneum

Conclusion: The study showed that haemodynamic changes during the intubation and laparoscopic surgeries were better controlled by Dexmedetomidine in comparison to Fentanyl.


Keywords


Anaesthetic Adjuvant, Dexmedetomidine, Fentanyl, Laparoscopic Surgeries

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