COMPARISON OF SERUM ANTIOXIDANT (ASCORBIC ACID AND TOCOPHEROL) LEVELS IN ANTENATAL WOMEN WITH AND WITHOUT PRETERM PREMATURE RUPTURE OF MEMBRANES

Nidhi Singh, Nisha Singh, Uma Singh, Abbas Ali Mahdi, Pushplata Sankhwar

Abstract


Background :Preterm premature rupture of membrane (PPROM) is a global contributor to preterm births and associated maternal morbidity and
perinatal morbidity and mortality . The exact cause of PPROM is unknown .Several studies point towards Reactive oxygen species (ROS) as
major contributor and in vitro studies have proved that antioxidants like Ascorbic acid and Tocopherol have synergistic protective effect against
ROS induced damage.
This study hypothesized that PPROM occurs due to decline in these antioxidant levels.
Method :97 antenatal women with PPROM were selected from 5672 antenatal women admitted during a period of one year at our tertiary care
teaching hospital . S. Ascorbic acid was estimated in 60 cases and 100 controls while S . Tocopherol levels in 55 cases (60 controls ) by method of
Omaye et al and modified method of Omu et al. respectively.
Results: Incidence of PPROM in the study was 1.7 % . The mean S. Ascorbic acid in cases was 0.726 mg/dl which was significantly lower than the
mean value of controls (1.434 mg/dl). The mean value of S. Tocopherol in cases was 0.248 mg/dl which was also significantly lower than the mean
value of 0.515 mg/dl among controls. It was observed that S. Ascorbic acid levels were significantly higher among women with longer leakingdelivery
interval.
Conclusion :Serum levels of both ascorbic acid and tocopherol were found to be significantly lower in pregnant women with preterm premature
rupture of membranes.


Keywords


Preterm Labor, Vitamin C, Vitamin E, Rupture Of Amniotic Membranes

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