A CROSS SECTIONAL STUDY TO ASSESS THE COGNITIVE FUNCTIONS OF PATIENTS ON CHRONIC STATIN THERAPY IN A TERTIARY CARE HOSPITAL

G Santhya, Yamuna devi

Abstract


INTRODUCTION: Statins are drugs which Act by lowering serum cholesterol levels and inhibiting enzymatic reactions
that lead to amyloid deposition and plaque formation; both considered cornerstone pathways leading to the development
of Alzheimer's disease.
OBJECTIVE:To assess the cognitive functions of patients on chronic statin therapy.
MATERIALS AND METHODS:This is a cross-sectional study done at Saveetha Hospital,Chennai. Patients were briefed and a written
informed consent was obtained. They were given a Mini Mental State Examination questionnaire and their scores were entered. The data, thus
collected was analyzed using SPSS software version 20
CONCLUSION: The study shows that as the duration of statin therapy increases, the risk of cognitive impairments also increase. On analyzing
the average Mini Mental State Examination scores, a constant decline of 3.33% was found between the subsequent groups as age increased and a
4% decline as a result of increased duration of statin therapy.


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