HBE BETA THALASSEMIA- A CASE REPORT HIGHLIGHTING THE NEED TO EXPECT THE UNEXPECTED

Dr. Abinaya Devi Annadurai, Dr. Renu Thambi, Dr. Jayalekshmy Payippat Leelamma, Dr. Sankar Sundaram

Abstract


Hemoglobin E (HbE) is common structural hemoglobin variant that occurs throughout many Asian countries at high
frequencies. Its coinheritance with beta thalassemia is called as haemoglobin E β thalassemia. They are expected to have a
moderately severe disease. Due to migration of people across the globe these inherited diseases are diagnosed in areas without documented disease
prevalence. Hemoglobin (Hb) electrophoresis and High- performance Liquid Chromoatography (HPLC) are required in the diagnosis of HbE beta
thalassemia. But definite diagnosis will require DNA testing. We report a case of 13 year old migrant female child suspected to have a
hemoglobinopathy by peripheral smear findings and diagnosed as HbE βthalassemia by Hb electrophoresis and HPLC.


Keywords


Hemoglobin(Hb) E, Hb electrophoresis, thalassemia.

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