RESULTS OF THE COMBINATION OF ORAL AND TOPICAL BETA - BLOCKERS IN THE TREATMENT OF GIANT ORBITO - PALPÉBRAL HEMANGIOMA : A CASE REPORT

H. Boutahar, C. Aabdi, L. El ayyadi, H. Abu rabie, S. Dikhay, S. Chariba, A. Maadane, R. Sekhsoukh

Abstract


Purpose: We discuss through a case report the results of using oral and topical beta blockers to treat a voluminous cutaneous and orbital capillary hemangioma. Observation: We report the case of a 2-month-old girl who had a large cutaneous and orbital capillary hemangioma of the left eye causing obstruction of the visual axis. Oral and topical beta-blockers  induced hemangioma regression. Discussion: Capillary hemangioma is the most common vascular tumor in children that usually regresses spontaneously. When complications such as amblyopia, strabismus, corneal exposure, optic nerve compression or malformations of the bony orbit occur; a rigorous management becomes compulsory. Beta-blockers generate abnormal vessels vasoconstriction, inhibition of the production of angiogenic factors and stimulation of endothelial cell apoptosis. They are effective during the involution of the hemangioma, unlike steroids which are active only during the proliferative period, which justifies our therapeutic choice. Conclusion: Oral beta-blockers have been shown to be effective in the treatment of severe and extensive forms of orbito-palpebral hemangiomas, and the results of the combination have shown added value of topical beta-blockers with rarely noted adverse effects.


Keywords


Capillary hemangioma, Eyelid , Orbit ,Amblyopia, Beta-blockers

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