A RETROSPECTIVE STUDY TO EVALUATE ASSOCIATION BETWEEN THYROID PEROXIDASE ANTIBODIES AND PREGNANCY OUTCOME

Dr Reeta Shukla, Dr. Meenakshi Devi, Dr. Anand Kumar

Abstract


Aim: study was to compare pregnancy outcome in euthyroid women who were anti-TPO-Ab positive with those who were anti TPO-Ab negative. Design: observational study method : comprised 500 women in the age group of 18-35 years, having normal thyroid function test normotensive, nondiabetic, singleton pregnancy attending OPD SRN Hospital Allahabad and Kamala Nehru Hospital in Prayagraj November 16 - October 17, all euthyroid pregnancy, those were already in process of abortion and those aborted in our hospital. Anti TPO-Ab level of > 50 IU/ml were considered as anti TPO-Ab positive. Main outcome:-  estimation of  proportion of anti TPO-Ab in women attending  OPD in  hospital and  comparison of maternal and neonatal out come in anti TPO- Ab Positive and anti TPO-Ab negative euthyroid women were done. RESULT:- increased rate of miscarriage (12.5 vs 2.39%) p <0.05, LBW ( 27.5 vs 5.217%) p < 0.05,and preterm birth (17.5 vs 3.4%) p < 0.05, in anti- TPO-Ab positive as compored to anti- TPO- Ab negative women. CONCLUSION- Study revealed anti-TPO- Ab is strongly associated with miscarriage, preterm birth irrespective of their gestational age, LBW is also significantly associated with anti-TPO-Ab positivity. However we did not find any correlation with other complication as found in studies by other authors.


Keywords


Thyroid peroxidise antibodies, euthyroid pregnancy, Autoimmunity.

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