ASSOCIATION BETWEEN LYMPHOCYTE-MONOCYTE RATIO (LMR) AND NUMBER OF CORONARY ARTERY LESIONS IN PATIENTS WITH ACUTE CORONARY SYNDROME

Miftahul Fadhly, Rahmad Isnanta, Zainal Safri

Abstract


Introduction : Acute coronary syndrome (ACS) is a term used to describe the spectrum of thrombotic
coronary artery disease.The basic disorder is atherosclerosis which will cause atheroma
plaque.Inammation has an important role in the process of atherosclerosis. Lower lymphocyte counts and higher monocytes
show clinical importance in many cardiovascular conditions. Multivariate analysis showed that LMR was an independent
predictor in groups with medium to high syntax scores
Aim : To determine the relationship between LMR value and the number of coronary artery lesions in patients with Acute
Coronary Syndrome
Methods : This was an observational study of 88 consecutive ACS patients who came to Adam Malik General Hospital Medan,
from July 2017 to July 2018. Evaluation of LMR value, blood tests, and coronary angiography were performed in each subject.
The number of coronary artery lesions were assessed by Vessel Score. Furthermore, the calculated LMR values are associated
with Vessel scores using Chi-Square analysis.
Results : From 88 research subjects, there were 35 (39,8%) subjects with Simple Vessel Disease (SVD) and 53 (60,3%) subjects
with Multi Vessel Disease (MVD).Based on the results of the ROC analysis, it was found that the LMR cut-off point value of the
Vessel Score was 1,221 with a sensitivity of 91,4% and specicity of 79.2% with a signicant strength (p <0.001). In the Chi-
Square analysis, there was a signicant relationship between LMR value and Vessel score (p <0.001).
Conclusion : There is a signicant relationship between LMR value and the number of coronary artery lesions in ACS patients.


Keywords


Acute Coronary Syndrome, LMR, Vessel Score, Angiography.

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