DIAGNOSTIC AND PROGNOSTIC IMPORTANCE OF CBC PARAMETERS IN EARLY DENGUE INFECTION: A STUDY OF 50 CASES IN TERTIARY TEACHING MEDICAL COLLEGES

Parshuram Prasad, Subhash Chandra Jha, Vijay Kumar Singh

Abstract


Background: Aim of study was to determine diagnostic and prognostic importance of change in CBC
parameters of NS1+ dengue patients. Certain change in TLC, DLC and HCT parameters could signify
dengue infection in febrile patients. Further serial CBC ndings could predict future course of disease.Dengue viruses (DV)
belong to family Flaviviridae and there are four serotypes of the virus referred to as DENV-1, DENV-2, DENV-3 and DENV-4. All
four serotypes can cause the full spectrum of disease from a subclinical infection to a mild self limiting disease, the dengue
fever (DF) and a severe disease that may be fatal, the dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS).It is
epidemic in urban areas of Bihar..
Material and methods: Epidemiological data and hematological parameters of 50 NS1 positive early dengue fever patients
were collected during epidemic period of July 2019 to October 2019 in tertiary teaching government medical colleges of Bihar,
India.
Result: Out of total number of 50 patients, female was 18 and male was 32, male female ratio was 1.8:1. Minimum age was 5
years and maximum age was 64 years.TLC was either normal or decreased, predominantly normal, low TLC was in 18 patients
and rest has normal TLC . .Differential showed usually normal neutrophil count or neutrophilia, 17 patients had neutrophilia
and 1 had neutropenia 5 patients revealed neutropenia with lymphocytosis and monocytosis. Platelet count was usually
normal range except thrombocytopenia in ve patients, one had<1,00,000/μL.
Conclusion: The study results were relevant in the characterization of biological markers in the evolution of the disease and
could be used as markers for early diagnosis and prognosis prediction thereby enabling health professionals in taking early
help with the adaption of therapeutic conduct for specic patients.


Keywords


Dengue, Dengue Fever, Dengue Shock Syndrome, NS1, Thrombocytopenia,Neutrophilia

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