A COMPARATIVE STUDY ON EFFICACY OF LIGNOCAINE AND DEXMEDETOMIDINE IN ATTENUATING THE PRESSOR RESPONSE TO LARYNGOSCOPY AND INTUBATION

Dr. Vishal Vinod, Dr. Naseem Akhtar, Dr Mohib Ahmed

Abstract


The present study was designed to compare the efficacy of Lignocaine and Dexmedetomidine in attenuating the pressor response to larynoscopy and intubation. 120 ASA I and II adult patients scheduled for elective surgery under general anesthesia were randomly divided into 2 groups of 60 patients each irrespective of age and sex into group L (Lignocaine) and group D (Dexmedetomidine) to receive either intravenous lignocaine 1.5 mg/kg body weight 3 minutes prior to intubation (Group L) or to receive intravenous dexmedetomidine 0.75 µg/kg body weight as infusion started 10 minutes before induction (Group D).

The heart rate, systolic, diastolic and mean arterial pressures were recorded basal (on entering the operation theater) before administration of study drug, after administration of the study drug, after induction and at 0, 2, 5, and 10 minutes after intubation. In both the groups there was definite rise in heart rate and blood pressure after intubation. Following administration of the study drug there was decrease in heart rate and mean arterial pressure in both the groups. There was decrease in heart rate after induction of anaesthesia which was greater in dexmedetomidine group compared to lignocaine group whereas the decrease in mean arterial pressure was lesser in dexmedetomidine group compared to lignocaine group. There was wide variation in heart rate and mean arterial pressure in lignocaine group compared to dexmedetomidine group.

The patients belonging to dexmedetomidine group were sedated but could be aroused easily on verbal command as compared to patients belonging to lignocaine group who were not sedated.


Keywords


Anaesthesia, Intubation, Pressor Response, Dexmedetomidine, Lignocaine.

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